Minichromosome maintenance

MCM2/3/5 family

Structure of MCM from archaeal M. Thermoautotrophicum.^[1]

Identifiers

Symbol

MCM

Pfam clan

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe
PDBsum	structure summary

Mini Chromosome Maintenance complex, or Minichromosome Maintenance protein complex or mini-chromosome maintenance (MCM) 2-7 helicase complex has a role in both the initiation and the elongation phases of eukaryotic DNA replication, specifically the formation and elongation of the replication fork. MCM is a component of the pre-replication complex, which is a component of the licensing factor. MCM is a hexamer of six related polypeptides (mcm2-7) that form a ring structure.^[3]^[4]

References

^ Fletcher RJ, Bishop BE, Leon RP, Sclafani RA, Ogata CM, Chen XS (March 2003). "The structure and function of MCM from archaeal M. Thermoautotrophicum". Nat. Struct. Biol. 10 (3): 160–7. doi:10.1038/nsb893. PMID 12548282.
^ Borlado LR, Méndez J (February 2008). "CDC6: from DNA replication to cell cycle checkpoints and oncogenesis". Carcinogenesis 29 (2): 237–43. doi:10.1093/carcin/bgm268. PMID 18048387.
^ ^a ^b Cortez D, Glick G, Elledge SJ (July 2004). "Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases". Proc. Natl. Acad. Sci. U.S.A. 101 (27): 10078–83. doi:10.1073/pnas.0403410101. PMC 454167. PMID 15210935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=454167.
^ Carpentieri F, De Felice M, De Falco M, Rossi M, Pisani FM (April 2002). "Physical and functional interaction between the mini-chromosome maintenance-like DNA helicase and the single-stranded DNA binding protein from the crenarchaeon Sulfolobus solfataricus". J. Biol. Chem. 277 (14): 12118–27. doi:10.1074/jbc.M200091200. PMID 11821426.

External links

Humphries C (2001-01-12). "Molecular Bureaucrat Tied to Replication Approval Process". Focus. Harvard Medical, Dental, and Public Health Schools. http://focus.hms.harvard.edu/2001/Jan12_2001/pathology1.html. Retrieved 2008-10-03.

DNA replication (Prokaryotic, Eukaryotic)

Separation
and initiation

Prokaryotic (initiation)	Pre-replication complex Cdc6 Helicase (dnaA, dnaB, T7) · Primase (dnaG)

Eukaryotic (preparation in G1 phase)	Pre-replication complex: Origin recognition complex (ORC1, ORC2, ORC3, ORC4, ORC5, ORC6) · Minichromosome maintenance (MCM2 · MCM3 · MCM4 · MCM5 · MCM6 · MCM7) · CDC6 Licensing factor Autonomously replicating sequence Single-strand binding protein (SSBP2, SSBP3, SSBP4) RNase H (RNASEH1, RNASEH2A) Helicase: HFM1 Primase: PRIM1 · PRIM2

Both	Origin of replication/Ori/Replicon Replication fork (Lagging and leading strands) · Okazaki fragment · Primer

Replication

Prokaryotic (elongation)	DNA polymerase III holoenzyme (dnaC, dnaE, dnaH, dnaN, dnaQ, dnaT, dnaX) · Replisome · DNA ligase · DNA clamp · Topoisomerase (DNA gyrase) Prokaryotic DNA polymerase: DNA polymerase I (Klenow fragment)

Eukaryotic (synthesis in S phase)	Replication factor C (RFC1) · Flap endonuclease (FEN1) · Topoisomerase · Replication protein A (RPA1) Eukaryotic DNA polymerase: delta (POLD1, POLD2, POLD3, POLD4) DNA clamp (PCNA)

Both	Movement: Processivity · DNA ligase

Termination

Telomere: Telomerase (TERT, TERC, DKC1)

see also DNA replication and repair-deficiency disorder
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

Minichromosome maintenance

See also

References

External links